Concentration of Rhenium-188 for the Radiopharmaceutical Synthesis

Introduction. Rhenium-188 has found wide application in nuclear medicine for the treatment of metastatic lesions skeletal system and joint diseases such as rheumatoid arthritis synovitis. Also, 188 Re-radiopharmaceuticals are being developed palliative hepatocellular carcinoma others. Immediately after first clinical trials Re-radiopharmaceuticals, when information on clinically effective administered doses radionuclide activity was obtained, use sodium perrenate, Re solutions with high volume radiopharmaceutical synthesis and, consequently, additional concentration obtained from generator became extremely relevant. Aim. Development technique solution, W/ "GREN-1" (State Research Center Russian Federation IPPE named Leipunsky, Obninsk, Russia) under laboratory conditions, comparison quality indicators resulting product Na ReO 4 solution an automatic module NEPTIS-TH (IRE, Belgium). Materials method. The objects this study were eluates manufactured by JSC (Obninsk, materials used production control these generators, well produced National Institute Radioelements Belgium) NEPTIS-TH. following methods to perrhenate, solutions: radiometry, thin layer chromatography, potentiometry, potentiometric titration, atomic absorption spectroscopy. Results discussion. efficiency eluate using cartridges filled cation exchanger Dowex® 50WX8 (100–200 mesh) (Sigma-Aldrich, USA, Cat. No. 217506) Al 2 O 3 pH mesh), IRE studied. yield rhenium-188 75–85 %. As a result process, there is no proportional increase content chemical impurities, it possible obtain cleaner metals Fe, Zn, Cu It that routine value radioactivity concentrated should not exceed 7.4–8.0 GBq/ml. Conclusion. conducted studies have shown task appropriate preparation radiopharmaceuticals therapy can be solved quite affordable materials, namely sequence cartridges. more preferable than manual assembly cartridges, based guaranteed assurance reducing dose burden personnel. However, tested incompatible domestic generator, so proposed registered Russia. results work will organize industrial modules cassettes complete set generator.